The MAC of sevoflurane is approximately what percentage?

• A. 2.05%
• B. 1.0%
• C. 4.0%
• D. 0.5%

Answer: (A)

The main idea here is MAC, which is the alveolar concentration of an inhaled anesthetic required to prevent movement in 50% of subjects in response to a surgical stimulus. It reflects potency—the lower the MAC, the more potent the drug.

Sevoflurane has a MAC of about 2% in adults at 1 atmosphere, so an approximate value around 2.05% is a close, commonly cited figure. This fits the idea that sevoflurane is moderately potent—not as potent as isoflurane (lower MAC) and far less potent than desflurane (much higher MAC).

In practice, you don’t stay exactly at MAC to maintain anesthesia; you adjust to a depth around 1.0–1.5 MAC with analgesia and adjuncts. Sevoflurane’s relatively low blood-gas solubility also helps with rapid changes in depth and quicker recovery.

Variations exist between species and individuals (for example, dogs may have a MAC around 2.3% or higher), but approximately 2.05% is a standard reference value for sevoflurane's MAC.