What does ketamine increase the demand of to tissues?

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Multiple Choice

What does ketamine increase the demand of to tissues?

Explanation:
Ketamine ramps up tissue metabolic activity, especially in the brain, which raises the amount of oxygen those tissues need to support that increased metabolism. This reflects an increased cerebral metabolic rate of oxygen (CMRO2) and the accompanying rise in blood flow to meet that demand. While glucose use also climbs with higher activity, the question targets what substrate’s demand rises in response to this heightened metabolism, and oxygen is the key one. CO2 is a waste product of metabolism, and ATP is produced using oxygen, but the immediate need driven by ketamine’s effect is greater oxygen consumption to fuel the higher metabolic rate.

Ketamine ramps up tissue metabolic activity, especially in the brain, which raises the amount of oxygen those tissues need to support that increased metabolism. This reflects an increased cerebral metabolic rate of oxygen (CMRO2) and the accompanying rise in blood flow to meet that demand. While glucose use also climbs with higher activity, the question targets what substrate’s demand rises in response to this heightened metabolism, and oxygen is the key one. CO2 is a waste product of metabolism, and ATP is produced using oxygen, but the immediate need driven by ketamine’s effect is greater oxygen consumption to fuel the higher metabolic rate.

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