What origin of suture material would cause the least amount of tissue reaction?

• A. Natural
• B. Hybrid
• C. Biogenic
• D. Synthetic

Answer: (D)

The main idea is how the body reacts to a suture material, which is driven by biocompatibility. Materials from natural sources tend to carry proteins and degradation products that can provoke a stronger inflammatory response, leading to more tissue reaction. Biogenic and hybrid sutures share some of these natural components or mixed properties, so they can still trigger noticeable tissue responses. Synthetic sutures, by contrast, are engineered polymers designed to be inert and stable in tissue, so they interact with the body far less and provoke only minimal inflammation. This inert, non-immunogenic nature means synthetic origin causes the least tissue reaction compared with natural or biologically derived sources.