Which drug is an example of a Kappa agonist?

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Multiple Choice

Which drug is an example of a Kappa agonist?

Explanation:
Kappa receptor activation provides analgesia with a profile that tends to produce less euphoria and can cause sedation or dysphoria. Butorphanol is a drug that acts as a kappa receptor agonist and also has mu receptor antagonism, so its analgesic effects come mainly from stimulating kappa receptors. This makes it the example of a Kappa agonist among the options. Naloxone is an opioid receptor antagonist, not an agonist. Buprenorphine is a partial mu agonist with high mu affinity and generally acts as a kappa antagonist, not a kappa agonist. Methadone is a full mu agonist, not kappa.

Kappa receptor activation provides analgesia with a profile that tends to produce less euphoria and can cause sedation or dysphoria. Butorphanol is a drug that acts as a kappa receptor agonist and also has mu receptor antagonism, so its analgesic effects come mainly from stimulating kappa receptors. This makes it the example of a Kappa agonist among the options. Naloxone is an opioid receptor antagonist, not an agonist. Buprenorphine is a partial mu agonist with high mu affinity and generally acts as a kappa antagonist, not a kappa agonist. Methadone is a full mu agonist, not kappa.

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