Which of the following is an example of a Kappa receptor agonist?

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Multiple Choice

Which of the following is an example of a Kappa receptor agonist?

Explanation:
Activation of kappa opioid receptors produces analgesia with less risk of respiratory depression compared with mu receptor activation, though it can cause sedation and dysphoria. Butorphanol fits this profile because it acts as a strong kappa receptor agonist while behaving as a mu receptor antagonist or weak mu agonist. In contrast, naloxone blocks opioid receptors (primarily mu), buprenorphine is a partial mu agonist with kappa antagonism, and methadone is a full mu agonist. Therefore, butorphanol is the correct example of a kappa receptor agonist.

Activation of kappa opioid receptors produces analgesia with less risk of respiratory depression compared with mu receptor activation, though it can cause sedation and dysphoria. Butorphanol fits this profile because it acts as a strong kappa receptor agonist while behaving as a mu receptor antagonist or weak mu agonist. In contrast, naloxone blocks opioid receptors (primarily mu), buprenorphine is a partial mu agonist with kappa antagonism, and methadone is a full mu agonist. Therefore, butorphanol is the correct example of a kappa receptor agonist.

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